ChemInform Abstract: Organolithium Mediated Synthesis of Prenylchalcones as Potential Inhibitors of Chemoresistance

Autor:	Jean Baptiste Daskiewicz, François Thomasson, Attilio Di Pietro, Denis Barron, Gilles Comte
Rok vydání:	2010
Předmět:	Chalcone chemistry.chemical_compound Prenylation Chemistry Stereochemistry Cancer cell Aldol condensation General Medicine Condensation reaction
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199948108
Popis:	A number of substituted chalcones have been prepared by a novel LiHMDS-mediated aldol condensation, the first method consistent with the use of alkali-labile protecting groups such as tert-butyldiphenylsilyl or tert-butyldimethylsilyl. Chalcone substitution by prenylation increases their binding affinity to P-glycoprotein responsible for cancer cells chemoresistance.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ebe5de49983d67fb3c3c4a47cedbcb2b https://doi.org/10.1002/chin.199948108 Zobrazit plný text záznamu Plný text