Fast detection of tumor marker CA 19-9 using AlGaN/GaN high electron mobility transistors
| Autor: | P.V. Wadekar, Shuchen Hsieh, Srinivasu Puttaswamy, Shi-Ya Hsu, Pei-Hsien Chen, Hay-Yan Jack Wang, Sheng-Hsiang Wang, Kuang-Hung Cheng, Kung-Kai Kuo, Chia-Chang Tsai, Ching-Wen Chang, Wen-Ti Hsu, Li-Wei Tu, Ying Sun |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
02 engineering and technology High-electron-mobility transistor 01 natural sciences law.invention chemistry.chemical_compound law Monolayer Materials Chemistry Electrical and Electronic Engineering High electron Instrumentation Tumor marker business.industry 010401 analytical chemistry Transistor Metals and Alloys Buffer solution 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Optoelectronics CA19-9 0210 nano-technology business Biosensor |
| Zdroj: | Sensors and Actuators B: Chemical. 267:191-197 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2018.04.008 |
| Popis: | Early detection of cancerous cells is crucial for successful treatment, hence active research has been focused on developing biomarkers based biosensors. Herein, we report the use of antibody-functionalized AlGaN/GaN high electron mobility transistor (HEMT) for a fast detection of the prominent tumor marker of carbohydrate antigen 19-9 (CA 19-9). The antibody of CA 19-9 was embedded to the sensing gate area of the HEMT device through self-assembled monolayer (SAM) technique. The source-drain current showed a swift response when the target CA 19-9 in a buffer solution at analytic concentrations was added to the antibody-immobilized surface. The lowest detectable concentration was 15 U/mL suitable for clinical detection of pancreatic cancer. Our experimental results clearly demonstrate the possibility of development of a portable HEMT sensor for rapid cancer screening and post-treatment tracking. |
| Databáze: | OpenAIRE |
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