Protective Effect of Schisandra chinensis Extract Against Ethanol-Induced Gastric Ulcers in Mice by Promoting Anti-inflammatory and Mucosal Defense Mechanisms
| Autor: | Yan-han Xuan, Hai-jing Fu, Xin-xin Hu, Guiying Xing, Wen-zhang Si, Zheng Liu, Jian Zhang, Ming-xiao Luo, Chen Shen, Hua-fang Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
Ethanol
biology 010405 organic chemistry business.industry medicine.drug_class Schisandra chinensis Pharmacology Malondialdehyde biology.organism_classification Ulcer index 01 natural sciences Anti-inflammatory 0104 chemical sciences Schisandraceae Superoxide dismutase 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry biology.protein Medicine Tumor necrosis factor alpha General Pharmacology Toxicology and Pharmaceutics business |
| Zdroj: | Revista Brasileira de Farmacognosia. 30:780-788 |
| ISSN: | 1981-528X |
| Popis: | Schisandra chinensis (Turcz.) Baill., Schisandraceae, is a common Chinese traditional medicine for the treatment of nervous system disorders and cardiovascular diseases. However, little is known about its efficacy in treating gastrointestinal diseases. In the present study, the protective effect of the ethanol extract of S. chinensis against ethanol-induced acute gastric lesions was investigated in mice. Furthermore, we developed a method based on high-performance liquid chromatography for the quantification of bioactive lignans with a dibenzocyclooctadiene skeleton. The ethanol extract of S. chinensis significantly decreased the ulcer index, sheltered mucosa from lesions, increased levels of superoxide dismutase, decreased malondialdehyde levels, and downregulated plasma levels of tumor necrosis factor-α and interleukin-1β. Our findings demonstrated the gastroprotective properties of the ethanol extract of S. chinensis. |
| Databáze: | OpenAIRE |
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