Validation of the 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis

Autor: Alessandro Tomelleri, Roberto Padoan, Chengappa G Kavadichanda, Augustine Jose, Kritika Singh, Luca Iorio, Upendra Rathore, Emma Rinaldi, Elena Baldissera, Vikas Agarwal, Lorenzo Dagna, Corrado Campochiaro, Durga Prasanna Misra
Rok vydání: 2023
Předmět:
Zdroj: Rheumatology.
ISSN: 1462-0332
1462-0324
DOI: 10.1093/rheumatology/kead161
Popis: Objectives The present study validates the 2022 ACR/European Alliance of Associations for Rheumatology (EULAR) classification criteria for Takayasu’s arteritis (TAK), compared with the 1990 ACR TAK classification criteria. Methods The fulfilment of 2022 ACR/EULAR and 1990 ACR TAK criteria from four referral centres was assessed for TAK compared with extracranial giant cell arteritis (EC-GCA) and other controls. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratio of a positive test (LR+) or negative test (LR–), and area under receiver operating characteristics curve (AUC) were calculated. Results Among 504 patients with TAK (404 females) and 222 controls (151 females, 144 patients with EC-GCA), the 2022 ACR/EULAR criteria had better sensitivity (95.83% vs 82.94%) and NPV, but poorer specificity (63.51% vs 90.54%), PPV, LR+, LR– and AUC at the pre-determined cut-offs than the 1990 ACR criteria. The 2022 ACR/EULAR criteria had greater specificity (76.06% vs 57.62%) and AUC (0.845 vs 0.771), with similar sensitivity (93% vs 96.53%) in males as in females. The 2022 ACR/EULAR criteria performed similarly with only EC-GCA as controls (sensitivity 95.83%, specificity 60.42%, AUC 0.781). Sensitivity remained similar, whereas specificity was higher for 40–60 years vs Conclusion The poor specificity of the 2022 ACR/EULAR TAK criteria in real-life settings was improved by increasing the cut-off to 6 or 7, or removing the point for female sex.
Databáze: OpenAIRE
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