Efficient Asymmetric Hydrogenation of .BETA.- and .GAMMA.-Amino Ketone Derivatives Leading to Practical Synthesis of Fluoxetine and Eprozinol
Autor: | Kazuo Achiwa, Shunji Sakuraba |
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Rok vydání: | 1995 |
Předmět: | |
Zdroj: | Chemical and Pharmaceutical Bulletin. 43:748-753 |
ISSN: | 1347-5223 0009-2363 |
Popis: | N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (BCPM)-rhodium(I) complexes were efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols. |
Databáze: | OpenAIRE |
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