Efficient Asymmetric Hydrogenation of .BETA.- and .GAMMA.-Amino Ketone Derivatives Leading to Practical Synthesis of Fluoxetine and Eprozinol

Autor:	Kazuo Achiwa, Shunji Sakuraba
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Ketone Hydrochloride medicine.drug_class Asymmetric hydrogenation General Chemistry General Medicine Optically active Eprozinol Pyrrolidine Aminoketone Catalysis chemistry.chemical_compound chemistry Drug Discovery medicine Organic chemistry
Zdroj:	Chemical and Pharmaceutical Bulletin. 43:748-753
ISSN:	1347-5223 0009-2363
Popis:	N-(Methylcarbamoyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (MCCPM)- and N-(tert-butoxycarbonyl)-4-(dicyclohexylphosphino)-2-[(diphenylphosphino)methyl]pyrrolidine (BCPM)-rhodium(I) complexes were efficient catalysts for asymmetric hydrogenations of β- and γ-amino ketone hydrochloride derivatives. Utilizing this methodology, we have developed efficient syntheses of fluoxetine and eprozinol from intermediate optically active amino alcohols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ebd21a7296f9786c3297802a9c5cd201 https://doi.org/10.1248/cpb.43.748 Zobrazit plný text záznamu