Triethyloxonium Tetrafluoroborate/1,2-Dimethoxyethane – a Versatile Substitute for Trimethyloxonium Tetrafluoroborate in O-Methylation Reactions

Autor:	Franz Bracher, Hermann Poschenrieder, Andrea Ritter
Rok vydání:	2009
Předmět:	chemistry.chemical_compound Chemistry Trimethyloxonium tetrafluoroborate General Chemistry Methylation Triethyloxonium tetrafluoroborate Medicinal chemistry Dimethoxyethane
Zdroj:	Zeitschrift für Naturforschung B. 64:427-433
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-2009-0412
Popis:	The triethyloxonium tetrafluoroborate/1,2-dimethoxyethane (TEO/DME) mixture is a versatile and cheap substitute for trimethyloxonium tetrafluoroborate in O-methylations of pyrrolin-2-ones, quinolones, acridones, and 1-oxo-β -carbolines. Undesired O-ethylation can be avoided by preincubation of triethyloxonium tetrafluoroborate and 1,2-dimethoxyethane for 1 h, prior to addition of the substrate. In the course of these investigations it was found that the structures assigned to the alkaloids taraxacine A and B are erroneous.
Databáze:	OpenAIRE
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