Correction par le lithium des neutropénies induites par la clozapine (deux cas)
| Autor: | A. Spreux, Guy Darcourt, F. Papetti, F. Feral, S. Thauby, D. Pringuey, J.-Y. Giordana |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Leukopenia Lithium (medication) business.industry medicine.medical_treatment Lithium carbonate Neutropenia medicine.disease Gastroenterology Surgery Psychiatry and Mental health chemistry.chemical_compound Arts and Humanities (miscellaneous) chemistry Internal medicine Absolute neutrophil count Medicine Leukocytosis medicine.symptom business Antipsychotic Clozapine medicine.drug |
| Zdroj: | L'Encéphale. 30:578-582 |
| ISSN: | 0013-7006 |
| DOI: | 10.1016/s0013-7006(04)95473-5 |
| Popis: | Despite the availability of new treatments, the antipsychotic effectiveness of clozapine has not been matched yet. Unfortunately, its regulation is limited by the side effects. The most detrimental is the hematologic toxicity (neutropenia and agranulocytosis) which requires a regular biological monitoring. Treatment with clozapine must be stopped in those cases of secondary granulocytopenia for about 3% of the patients. The current psychiatric drug lithium carbonate has an opposite effect: it can induce leukocytosis. Thus, lithium carbonate is administered in leukopenia, as well as in many hematologic and immunological diseases. However, few teams have used lithium in order to alleviate clozapine-induced granulocytopenia. We report here 2 patients who developed severe neutropenia (neutrophil count |
| Databáze: | OpenAIRE |
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