The role of radiation therapy in treatment of small cell undifferentiated bronchogenic carcinoma
| Autor: | H.Thomas Barkley, B.S. Ajaikumar |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Chemotherapy Radiation business.industry medicine.medical_treatment Cell Mediastinum Disease Bronchogenic carcinoma Radiation therapy medicine.anatomical_structure Lymphatic system Internal medicine medicine Adjuvant therapy Radiology Nuclear Medicine and imaging Radiology business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 4:101 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(78)90266-3 |
| Popis: | The current enthusiasm for polychemotherapy in small cell undifferentiated bronchogenic carcinoma obscures the necessity for primary control by radiation therapy. One hundred sixty-three patients with this diagnosis were treated in the periods 1965-1967 (56) and 1974-1976 (107). In the earlier period patients received radiation alone or radiation plus single agent chemotherapy. In the latter period, all patients were treated with multiple agent chemotherapy in addition to radiation therapy. Median Survival Time was extended approximately 4 weeks for the latter group of patients at the cost of much morbidity and occasional lethality. In the patients autopsied from both series, only 5/30 were free of disease within the treatment portals and all had received more than 4,000 rad tumor dose regardless of adjuvant therapy. A total of 14 autopsies were performed on patients treated by chemo-immunotherapy alone during the 1973-1976 period. All of these revealed disease in the primary site and mediastinum although some had no evidence of distant metastasis. Tumor volume is sufficiently large within the primary site and regional lymphatics that presently available chemo-immunotherapy without high dose irradiation is unlikely to sterilize loco-regional disease. Elective radiation to the whole brain was administered to 25 patients and only 3 developed cerebral metastases. Of the concurrently treated remaining 82 patients, 25 developed cerebral metastases which were treated as they were manifest. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|