Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites

Autor:	José Mauro Granjeiro, Carlos A. Achete, Marcelo Sanmartin de Almeida, Lídia Ágata de Sena, Igor Iuco Castro-Silva, Gustavo Vicentis de Oliveira Fernandes, Rosa Mayelín Guerra Bretaña
Rok vydání:	2014
Předmět:	Materials science Biocompatibility Composite number Biomedical Engineering engineering.material Matrix (biology) Wollastonite law.invention Biomaterials In vivo Cyanoacrylate law engineering Adhesive Composite material skin and connective tissue diseases Pseudowollastonite
Zdroj:	Journal of Biomedical Materials Research Part B: Applied Biomaterials. 102:1121-1129
ISSN:	1552-4973
DOI:	10.1002/jbm.b.33093
Popis:	Wollastonite-poly(n-butyl-2-cyanoacrylate) composite (W-BCA) has been proposed to immobilize anatomically bone fragments in order to achieve an optimal healing process. The present study evaluated the in vitro and in vivo behavior of three types of fillers: powdered natural wollastonite (Wn), synthetic pseudowollastonite powder (Ws), and synthetic pseudowollastonite powder coated with 5% acetyl tributyl citrate (Wst). The Wst-BCA composite underwent a higher degradability in the real-time degradation test and a superior cytotoxic effect; whereas the Wn-BCA composite showed a higher degradability in the accelerated test with no cytotoxicity. The formation of an extracellular collagenous matrix deposit on its surface and the most favorable new bone formation on Wn-BCA indicate its potential for bone adhesive use in unstable orthopedic traumas.
Databáze:	OpenAIRE
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