| Autor: |
G. A. A. Kivitis, D. H. Nugteren, E. Christ-Hazelhof |
| Rok vydání: |
1983 |
| Předmět: |
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| Zdroj: |
Atherosclerosis VI ISBN: 9783642818196 |
| DOI: |
10.1007/978-3-642-81817-2_126 |
| Popis: |
The discovery in 1971 (1) that non-steroidal anti-inflammatory drugs such as aspirin and indomethacin inhibit prostaglandin biosynthesis, was the first indication of a connection between the enzymic oxygenation of arachidonic acid (20:4) and inflammation. Some years later, it was shown that human adherent rheumatoid synovial cells had a high potency for PG-biosynthesis (2). The detection of an arachidonate-5-lipoxygenase in glycogen-elicited rabbit peritoneal polymorphonuclear leukocytes (PMN’s) (3) has recently culminated in the discovery that slow-reacting substances in anaphylaxis and leukotactic factors are also arachidonate metabolites. All these substances are now known under the general name “eicosanoids” and play important regulatory roles in the cell. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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