Improving hyperthermia treatment planning for the pelvis by accurate fluid modeling
| Autor: | J. Sijbrands, G. Schooneveldt, J.J.M.C.H. de la Rosette, Maarten C.C.M. Hulshof, Johannes Crezee, Elisabeth D. Geijsen, F. van Ommen, T.M. De Reijke, Edmond Balidemaj, A. Bakker, H. P. Kok |
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| Rok vydání: | 2016 |
| Předmět: |
Hyperthermia
medicine.medical_specialty Materials science Urinary bladder Bladder cancer medicine.medical_treatment Hyperthermia Treatment General Medicine medicine.disease Imaging phantom 030218 nuclear medicine & medical imaging Surgery Radiation therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Radiation treatment planning Pelvis Biomedical engineering |
| Zdroj: | Medical Physics. 43:5442-5452 |
| ISSN: | 0094-2405 |
| Popis: | Purpose: Hyperthermia is an established (neo)adjuvant treatment modality for a number of pelvic malignancies. Optimal treatment of these tumors requires robust treatment planning, but up until now, the urinary bladder was not modeled accurately, making current simulations less reliable. The authors improved the dielectric and thermophysical model of the urinary bladder in their treatment planning system, and showed the improvements using phantom experiments. Methods: The authors suspended a porcine bladder in muscle tissue equivalent gel and filled it with 120 ml 0.9% saline. The authors heated the phantom during 15 min with their deep hyperthermia device, using clinical settings, and measured the temperature both inside and outside the bladder. The authors simulated the experiment, both using the clinically used treatment planning system, and using the improved model featuring correct dielectric properties for the bladder content and an enhanced thermophysical model, enabling the simulation of convection. Results: Although the dielectric changes have an impact throughout the phantom, the dominant effect is a higher net heat absorption in the bladder. The effects of changing the thermophysical model are limited to the bladder and its surroundings, but result in a very different temperature profile. The temperatures predicted by the simulations using the new bladder model were in much better agreement with the measurements than those predicted by currently used treatment planning system. Conclusions: Modeling convection in the urinary bladder is very important for accurate hyperthermia treatment planning in the pelvic area. |
| Databáze: | OpenAIRE |
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