Abstract 465: The CB2 Cannabinoid Receptor Mediates the Anti-Proliferative Actions of Angiotensin-(1-7) in Vascular Smooth Muscle Cells
| Autor: | E. Ann Tallant, Allyn Howlett, Megan Grabenauer, Brian F Thomas, Patricia E Gallagher |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Hypertension. 62 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Therapeutic interventions to reduce vascular proliferation are critical for the effective treatment of hypertension-induced end-organ damage, restenosis and atherosclerosis. We showed that angiotensin-(1-7) [Ang-(1-7)] reduces neointimal formation following vascular injury and inhibits vascular growth, through activation of the AT7 receptor mas and production of arachidonic acid derivatives. Endocannaboids (ECs) derived from membrane phospholipids also inhibit vascular proliferation and reduce growth following vascular injury, by stimulation of the CB2 receptor. The impact of CB2 receptor blockade on the anti-proliferative actions of Ang-(1-7) was investigated to assess a potential interaction between the EC and Ang-(1-7)/mas receptor systems. Rat thoracic aortic vascular smooth muscle cells (VSMCs) were treated with platelet-derived growth factor (PDGF) to stimulate growth and incubated with Ang-(1-7), the AT7 receptor antagonist [D-alanine7]-angiotensin-(1-7) [Dala], the CB2 receptor agonist HU308 and/or the CB2 receptor antagonist AM630. PDGF-stimulated VSMC growth was markedly reduced by Ang-(1-7) (74 ± 6% of control, n = 10, p |
| Databáze: | OpenAIRE |
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