Benzofuran systems. Regioselective bromination and some other reactions of 1-(3-benzofuranyl)-2-phenylethanones

Autor:	Ernst Baumann, Halina Kwiecien
Rok vydání:	1998
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry medicine Regioselectivity Halogenation Benzofuran Lithium aluminium hydride Carbonyl group Medicinal chemistry Chloride medicine.drug
Zdroj:	Journal of Heterocyclic Chemistry. 35:1501-1503
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570350647
Popis:	1-[3-(2-Alkylbenzofuranyl)]-2-(3,5-dibromo-4-hydroxyphenyl)ethanones 5a,b and 1-[3-(2-alkylbenzofuranyl)-2-(3-bromo-4-methoxyphenyl)ethanones 3a,b were readily prepared by selective bromination of hydroxy 1a,b and methoxy 1c,d ethanones, respectively. A successful method of O-alkylamination of 5a with N-(2-chloroethyl)-N,N-diethylammonium chloride to 6a by a two-phase reaction under phase transfer conditions has been applied. Lithium aluminium hydride reduction of the carbonyl group of 1b to carbinol 4b was carried out in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ebaddcb7775c8a6c89470804bdd2079e https://doi.org/10.1002/jhet.5570350647 Zobrazit plný text záznamu Plný text