| Popis: |
Click chemistry is an extremely powerful method for covalent conjugation of molecular entities quickly and efficiently. Click chemistry knitted the threads between two different molecular entities that have created interesting structures for more than 15 years with a wide range of applications, including in interesting fields such as synthetic chemistry, medicinal science, biochemistry, material science, pharmacology and catalysis. Due to the schematic modification and incorporation of azide and alkyne groups within biological scaffolds, azide-alkyne cycloaddition (AAC) is still the leading methodology among click chemistry. This review focuses on the mechanism, scope, and applications of the CuAAC reaction, RuAAC reaction, and the recent development of photo-click reactions, and their applications cover the literature from the last ten years. |
