Synthesis and Biological Activity of 2-Mercapto-7,10-Dimethyl-3H-Spiro[Benzo[H]Quinazoline-5,1′-Cyclopentane]-4(6H)-One from Ethyl 4′-Amino-5′,8′-Dimethyl-1′H-Spiro[Cyclopentane-1,2′-Naphthalene]-3′-Carboxylate

Autor:	A. I. Markosyan, N. P. Grigoryan, R. S. Sukasyan, R. G. Paronikyan, A. S. Grigoryan, G. A. Stepanyan
Rok vydání:	2018
Předmět:	Pharmacology chemistry.chemical_classification 010405 organic chemistry Biological activity Ring (chemistry) 01 natural sciences Medicinal chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Drug Discovery Quinazoline Carboxylate Benzene Cyclopentane Alkyl Naphthalene
Zdroj:	Pharmaceutical Chemistry Journal. 51:1057-1062
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1740-6
Popis:	A synthetic method for 7,10-dimethyl-2-thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazoline-5,1′-cyclopentane]- 4(6H)-one from ethyl 4′-amino-5′,8′-dimethyl-1′-H-spiro[cyclopentane-1,2′-naphthalene]-3′-carboxylate was developed. Reaction of the spirobenzo[h]quinazoline with various alkyl(benzyl) halides synthesized a novel series of spirobenzo[h]quinazolines containing methyl substituents on the benzene ring. The antidepressant, anticonvulsant, and antibacterial activities of the synthesized spirobenzo[h]quinazolines were investigated.
Databáze:	OpenAIRE
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