Novel HPLC-Based Screening Method to Assess Developability of Antibody-Like Molecules
| Autor: | Melissa Geddie, Neeraj Kohli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chromatography biology Chemistry Size-exclusion chromatography 030226 pharmacology & pharmacy High-performance liquid chromatography 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Protein stability Antibodies monoclonal Biological property biology.protein Screening method Molecule Antibody |
| Zdroj: | Methods in Molecular Biology ISBN: 9781493968558 |
| Popis: | The discovery of antibodies that bind to targets with high affinity is now a routine exercise. However, it is still challenging to screen for candidates that, in addition to having excellent biological properties, also have optimal biophysical characteristics. Here, we describe a simple HPLC-based screening method to assess for developability factors earlier in the discovery process. |
| Databáze: | OpenAIRE |
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