| Autor: |
Ramy Mohamed Abd Elaziz, Abdu Saad El Tabl, Moshira M. Abd El-Wahed, Mohamed M. Elmazar |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Egyptian Journal of Chemistry. 63:389-404 |
| ISSN: |
2357-0245 |
| DOI: |
10.21608/ejchem.2019.13511.1837 |
| Popis: |
Interaction between vanadium pentoxide and bioactive Schiff–bases led to the formation of vanadium (III/IV) complexes. Ten complexes have been characterized using mass, IR, UV-VIS and ESR spectra, magnetic moments and conductance measurements as well as elemental and thermal analyses. Magnetic moments and ESR measurements confirmed vanadium complexes have (III/IV) oxidation state. Conductivity measurements indicate that complexes are not electrolytes. A representative set of vanadium (III/IV) complexes in varying coordination environments have been tested as anti-hyperglycemic agents against type 2 diabetes mellitus in concentration doses (30 and 100 µM/Kg) using female albino rats. The pharmacological data showed that, complexes 1 and 8 produced significant decrease in blood glucose level. Furthermore, these two complexes showed an improvement in liver and kidney function after daily administration for two weeks. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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