Incarnatapeptins A and B, Nonribosomal Peptides Discovered Using Genome Mining and 1H/15N HSQC-TOCSY
| Autor: | Kalindi D Morgan, David E. Williams, Marianne D. Sadar, Katherine S. Ryan, Carmen Adriana Banuelos, Marion Remigy, Raymond J. Andersen, Brian O. Patrick |
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| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Chemistry Drug discovery Organic Chemistry In vitro cytotoxicity Combined use Computational biology 010402 general chemistry 01 natural sciences Biochemistry 3. Good health 0104 chemical sciences Chemical diversity LNCaP Screening method Genome mining Physical and Theoretical Chemistry Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Organic Letters. 22:4053-4057 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.0c00818 |
| Popis: | Methods for the focused isolation of low-abundance natural products with specific chemical substructures could expand known bioactive chemical diversity for drug discovery. Here we report the combined use of genome mining and an 15N NMR-based screening method for the targeted isolation of the low-abundance piperazic-acid-containing peptides incarnatapeptins A (1) and B (3). Incarnatapeptin B (3) shows in vitro cytotoxicity to LNCaP prostate cancer cells. |
| Databáze: | OpenAIRE |
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