Propargylamine (secondary) as a building block in indole synthesis involving ultrasound assisted Pd/Cu-catalyzed coupling-cyclization method: Unexpected formation of (pyrazole)imine derivatives

Autor:	Gautham G. Shenoy, P.S.V.K. Sri Saranya, Manojit Pal, B. Sridhar, Raghu Chandrashekhar Hariharapura, Suresh Babu Nallapati, Varadaraj Bhat Giliyaru, Gangireddy Sujeevan Reddy
Rok vydání:	2018
Předmět:	010405 organic chemistry Organic Chemistry Imine Pyrazole 010402 general chemistry Ultrasound assisted 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Drug Discovery Indole synthesis Moiety Linker
Zdroj:	Tetrahedron Letters. 59:4587-4592
ISSN:	0040-4039
Popis:	Propargylamine (secondary) has been explored as a building block in synthesizing indoles via an ultrasound assisted Pd/Cu-catalyzed coupling-cyclization method. Indoles containing a pyrazole moiety at C-2 attached via the –CH2NH– linker (designed as potential anti-tubercular agents) were synthesized first and then generality/scope of the methodology was expanded by synthesizing other indoles. Unexpected formation of imine side products in first cases helped in synthesizing related (pyrazole)imines via a Cu catalyzed ultrasound assisted aerobic oxidation of precursor amines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eb90b9be4667c7eed46b6713a397ec75 https://doi.org/10.1016/j.tetlet.2018.11.037 Zobrazit plný text záznamu Full Text from ScienceDirect