HIV-1 Genetic Diversity in Recently Diagnosed Infections in Moscow: Predominance of AFSU, Frequent Branching in Clusters, and Circulation of the Iberian Subtype G Variant
| Autor: | Khoren Epremyan, Andrei E. Siniavin, Lucía Pérez-Álvarez, Karamov Ev, Mónica Sánchez-Martínez, Ali Turgiev, Michael M. Thomson, Kornilaeva Gv, Cristina Carrera, Joan Bacqué, María Teresa Cuevas, Yury Zhernov, Elena Delgado |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
education.field_of_study Genetic diversity Immunology Population Human immunodeficiency virus (HIV) Biology medicine.disease_cause Virology Men who have sex with men 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases medicine 030212 general & internal medicine education Soviet union Clade |
| Zdroj: | AIDS Research and Human Retroviruses. 34:629-634 |
| ISSN: | 1931-8405 0889-2229 |
| Popis: | HIV-1 protease-reverse transcriptase sequences from 62 HIV-1-infected individuals recently diagnosed in Moscow were analyzed. Subtype A former Soviet Union (FSU) (AFSU) variant was the predominant clade (62.9%), followed by subtype B (22.6%), unique recombinants (6.5%), subtype G (6.5%), and CRF01_AE (1.6%). AFSU predominated among people who inject drugs (88.9%) and heterosexually acquired infections (77.8%), while subtype B was the most prevalent genetic form among men who have sex with men (44%), although AFSU was also frequent in this population (36%). Forty-eight (77.4%) viruses branched within intrasubtype clusters, three of which, of subtype B, had a majority of viruses collected outside of FSU. The four subtype G viruses identified in this study belonged to the Portuguese-Spanish (Iberian) variant and, together with three from databases, formed a Russian cluster closely related to viruses from Denmark. This is the first report of the circulation of the Iberian subtype G variant in Russia. |
| Databáze: | OpenAIRE |
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