A Chemo-poroelastic Analysis of Mechanically Induced Fluid and Solute Transport in an Osteonal Cortical Bone
| Autor: | J. G. Janes, Zhi-He Jin, M. L. Peterson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Mechanical load 0206 medical engineering Poromechanics Biomedical Engineering chemistry.chemical_element 02 engineering and technology Calcium 020601 biomedical engineering Bone remodeling Osteon medicine.anatomical_structure chemistry Flow velocity Permeability (electromagnetism) medicine Biophysics Cortical bone |
| Zdroj: | Annals of Biomedical Engineering. 49:299-309 |
| ISSN: | 1573-9686 0090-6964 |
| Popis: | It is well known that transport of nutrients and wastes as solute in bone fluid plays an important role in bone remodeling and damage healing. This work presents a chemo-poroelastic model for fluid and solute transport in the lacunar-canalicular network of an osteonal cortical bone under cyclic axial mechanical loading or vascular pressure. Analytical solutions are obtained for the pore fluid pressure, and fluid and solute velocities. Numerical results for fluid and calcium transport indicate that under a cyclic stress of 20 MPa, the magnitudes of the fluid and calcium velocities increase with an increase in the loading frequency for the frequency range considered (≤ 3 Hz) and peak at the inner boundary. The peak magnitude of calcium velocity reaches 18.9 μm/s for an osteon with a permeability of 1.5 × 10−19 m2 under a 3 Hz loading frequency. The magnitude of calcium velocity under a vascular pressure of 50 mmHg is found to be two orders of magnitude smaller than that under the mechanical load. These results have the potential to be important in understanding fundamental aspects of cortical bone remodeling as transport characteristics of calcium and other nutrients at the osteon scale influence bone metabolism. |
| Databáze: | OpenAIRE |
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