Development of sulfanegen for mass cyanide casualties
| Autor: | Steven E. Patterson, Jacquie E. Briggs, Chakravarthy V. Vinnakota, Robert Vince, Brian A. Logue, Bryant Moeller, Herbert T. Nagasawa, Daune L. Crankshaw, Michael W. Stutelberg |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Sulfanegen CYANIDE EXPOSURE business.industry General Neuroscience Cyanide medicine.medical_treatment General Biochemistry Genetics and Molecular Biology Toxicology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine History and Philosophy of Science Respiratory failure chemistry Detoxification medicine Cyanide poisoning Intensive care medicine business Antidote 030217 neurology & neurosurgery CYANIDE ANTIDOTES |
| Zdroj: | Annals of the New York Academy of Sciences. 1374:202-209 |
| ISSN: | 0077-8923 |
| DOI: | 10.1111/nyas.13114 |
| Popis: | Cyanide is a metabolic poison that inhibits the utilization of oxygen to form ATP. The consequences of acute cyanide exposure are severe; exposure results in loss of consciousness, cardiac and respiratory failure, hypoxic brain injury, and dose-dependent death within minutes to hours. In a mass-casualty scenario, such as an industrial accident or terrorist attack, currently available cyanide antidotes would leave many victims untreated in the short time available for successful administration of a medical countermeasure. This restricted therapeutic window reflects the rate-limiting step of intravenous administration, which requires both time and trained medical personnel. Therefore, there is a need for rapidly acting antidotes that can be quickly administered to large numbers of people. To meet this need, our laboratory is developing sulfanegen, a potential antidote for cyanide poisoning with a novel mechanism based on 3-mercaptopyruvate sulfurtransferase (3-MST) for the detoxification of cyanide. Additionally, sulfanegen can be rapidly administered by intramuscular injection and has shown efficacy in many species of animal models. This article summarizes the journey from concept to clinical leads for this promising cyanide antidote. |
| Databáze: | OpenAIRE |
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