| Autor: |
Rui M.P. da Silva-Júnior, Ricardo Z. N. Vêncio, Izilda Aparecida Cardinalli, Fernando Silva Ramalho, Sonir Roberto Rauber Antonini, Fernanda Borchers Coeli-Lacchini, Margaret de Castro, Ayrton Custódio Moreira, Carlos Augusto Fernandes Molina, Carlos Alberto Scrideli, Silvio Tucci, José Andrés Yunes, Leandra Naira Zambelli Ramalho, Junier Marrero Gutiérrez, Ana Carolina Bueno, Silvia Regina Brandalise, Monica F Stecchini |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of the Endocrine Society. 5:A99-A100 |
| ISSN: |
2472-1972 |
| Popis: |
Pediatric adrenocortical tumors (pACTs) display complex genomic background and lack robust prognostic biomarkers. However, pACT methylation profiling was recently associated with patient prognosis. In order to evaluate whether tumor DNA methylation is associated with patient prognosis, we studied a Brazilian cohort of pACT in which most of the patients were carriers of the germline P53 p.R337H mutation (86%). We analyzed the DNA methylation profile of 57 tumor samples (MethylationEPIC BeadChip Array, Illumina) and the respective patients’ clinicopathological features associated with outcome and overall survival. Median age at diagnosis of the 40 girls and 17 boys was 2.1 years (range: 0.2–16.6). Reduced overall survival was observed in patients diagnosed after 4 years of age (n=43, HR=26.5, p2) between the groups was 0.084% (n=642 probes). Tumors from pACT1 were enriched for hypomethylation in genes’ body region and for hypermethylation in promoter regions (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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