Preparation of 13C8 derivatives of naphthalene, octachloronaphthalene and two hexachloronaphthalenes
| Autor: | M. Malaiyandi, P. Auger, D. T. Williams, R. H. Wightman |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Organic Chemistry
chemistry.chemical_element Biochemistry Medicinal chemistry Analytical Chemistry chemistry.chemical_compound Acetic acid Sodium borohydride chemistry Succinic acid Yield (chemistry) Drug Discovery Organic chemistry Radiology Nuclear Medicine and imaging Dehydrogenation Benzene Spectroscopy Palladium Naphthalene |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 33:263-276 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2580330404 |
| Popis: | A mild high yield sequence is reported for the synthesis of (13C8) naphthalene from (13C6) benzene and (13C2) succinic acid involving Friedel-Crafts condensation, Wolff-Kishner reduction, polyphosphoric acid cycliacylation, sodium borohydride reduction and palladium dehydrogenation. Perchlorination of (13C8) naphthalene gave a good yield of (13C8) octachloronaphthalene from which the (13C8) hexachloronaphthalenes were obtained by zinc/acetic acid reduction. |
| Databáze: | OpenAIRE |
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