Production of a Short-Lived Therapeutic α-Emitter 149Tb by Irradiation of Europium by 63 MeV α-Particles

Autor:	V. I. Novikov, S. T. Latushkin, V. N. Unezhev, V. A. Zagryadskiy, A. G. Kazakov, A. N. Moiseeva, R. A. Aliev
Rok vydání:	2021
Předmět:	Materials science Isotope medicine.medical_treatment Radiochemistry chemistry.chemical_element Terbium Nuclear Energy and Engineering chemistry Radioimmunotherapy medicine α emitter Irradiation Europium α particles
Zdroj:	Atomic Energy. 129:337-340
ISSN:	1573-8205 1063-4258
Popis:	149Tb is currently considered to be a promising α-emitting isotope radioimmunotherapy. It is shown that it can be obtained without the use of a carrier by irradiating a target consisting of Eu2O3 with 4He with energy 63 MeV. After irradiation, radiochemical separation of terbium radioisotopes was performed in a time not exceeding the half-life of 149Tb (4.12 h). It was based on reductive co-precipitation of europium and extraction-chromatographic purification. The obtained product, including 149Tb and the associated terbium radioisotopes, were analyzed by means of alpha- and gamma-spectrometry. It was concluded that the combination and sequence of approaches used in this work allow rapid production of short-lived 149Tb and the use of the technological route implemented in this work in practice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eb44cf49fc8620bd70060da2d2755a88 https://doi.org/10.1007/s10512-021-00758-z Zobrazit plný text záznamu Full text from SpringerLink