Effects on menopausal symptoms and acceptability of isoflavone-containing soy powder dietary supplementation
| Autor: | D. C. Knight, J B Howes, John A. Eden, L. G. Howes |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.drug_class Incidence (epidemiology) Obstetrics and Gynecology Physiology General Medicine Isoflavones medicine.disease Placebo law.invention Menopause chemistry.chemical_compound Sex hormone-binding globulin Endocrinology Randomized controlled trial chemistry law Estrogen Internal medicine medicine biology.protein business Adverse effect |
| Zdroj: | Climacteric. 4:13-18 |
| ISSN: | 1473-0804 1369-7137 |
| Popis: | Objectives: To assess the acceptability of the delivery of an isoflavone supplementation in the form of a powdered drink, and whether the supplementation of dietary isoflavones in this manner decreased the incidence of menopausal flushes. The secondary aims included assessment of other symptoms or parameters of estrogen deficiency and responses to isoflavones. Methods: A randomized, double-blind, placebo-controlled, parallel-group trial comprising 24 postmenopausal women with symptoms of estrogen deficiency was performed over a 12-week period. The women were randomized to receive a dietary beverage containing isoflavones or an isoflavone-free, isocaloric placebo preparation. Results: Although there was a high compliance rate among individual patients, there was a 25% withdrawal rate from the study in the active group. The incidence of complaints of bad taste tended to be higher in the active group (p = 0.07), and the total number of adverse events was significantly higher in this group (p < 0.001). There ... |
| Databáze: | OpenAIRE |
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