Sartoryglabrins, Analogs of Ardeemins, from Neosartorya Glabra

Autor:	Artur M. S. Silva, Sónia F. A. Santos, Leka Manoch, Anake Kijjoa, Werner Herz, M. H. Vasconcelos, Luís Gales, Ana R.R.P. Almeida, Tida Dethoup
Rok vydání:	2011
Předmět:	Pharmacology Neosartorya glabra Indole test biology Chemistry Melanoma Plant Science General Medicine Fungus medicine.disease biology.organism_classification Human tumor Complementary and alternative medicine MCF-7 Prenylation Biochemistry Cell culture Drug Discovery medicine
Zdroj:	Natural Product Communications. 6:1934578X1100600
ISSN:	1555-9475 1934-578X
DOI:	10.1177/1934578x1100600615
Popis:	Chemical investigation of a collection of the fungus Neosartorya glabra from Thailand furnished sartoryglabins A-C (1a, 1b and 2) which are analogs of the reverse prenylated indole alkaloids known as (-) ardeemins. Structures of these compounds were established by NMR spectrometry and an X-ray analysis. Sartoryglabins A-C were evaluated for their in vitro growth inhibitory activity on three human tumor cell lines: MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and A375-C5 (melanoma). All the compounds exhibited strong to moderate activity against the MCF-7 cell line but weak or no activity against the NCI-H460 and A375-C5 cell lines. Sartoryglabin B was found to exhibit selectivity towards the MCF-7 cell line.
Databáze:	OpenAIRE
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