Highly loaded COOH functionalized silica particles
| Autor: | Reut Cohen, Chaim N. Sukenik |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Silanes Materials science Biomolecule Dispersity 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Hydrolysis Colloid and Surface Chemistry chemistry Chemical engineering Particle Surface modification Organic chemistry Particle size 0210 nano-technology Pendant group |
| Zdroj: | Colloids and Surfaces A: Physicochemical and Engineering Aspects. 504:242-251 |
| ISSN: | 0927-7757 |
| DOI: | 10.1016/j.colsurfa.2016.05.027 |
| Popis: | Highly functionalized monodisperse silica particles are attractive as unique additives and fillers and as carriers for biomolecule immobilization. Uniform micron and nanometer scale silica particles are well known and coating methods have been developed for their surface modification. However, such coatings provide only limited loading capacity. Hybrid silica particles whose physical and chemical properties are controlled by a very high loading of non-hydrolyzable pendant group have been developed based on different functionalized silanes. The more polar and/or reactive the pendant functionality, the more difficult it is to achieve uniform, stable, particle formation. Nevertheless, making hybrid particles with masked carboxylic acids is a worthwhile goal since they should enable the production of highly acid-functionalized particles. Various kinds of protected carboxylic acids have been considered and their respective advantages and disadvantages have been established. These included esters and thioesters wherein deprotection is by hydrolysis, and terminal olefins wherein the acid group is created by ozonolysis. Systems were identified wherein particle synthesis and subsequent installation of carboxylic acids could be achieved in high yield and with excellent control over particle size and uniformity. The loading of acid groups in these particles has been established and the ability to use these acid groups for anchoring active biomolecules has been demonstrated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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