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Aim: The aim of the study was focused to determine is there a statistically significant difference of the use of oxygen during out-of hospital cardiac arrest (OHCA) patients on scene or in the ambulance car during transport and the airway management compared to achieved return of spontaneous circulation (ROSC). Methods: During this study, the datas' form EuReCa_Srbija register have been used for the period January 2016 -June 2017. The analyzed data's from EuReCa_Srbija register has been uploaded by lead investigators, collected during emergency medical services (EMS) interventions in patients with OHCA in Vojvodina. The statistical program of SPSS processed collected data's. The analizes of variance was applied. Results: In observed period in Vojvodina, 589 OHCA accured and treated by EMS. CPR was applied in Mere 419/589 (71%) cases where 144/419 (34%) were female and 275/419 (66%) male gender. The average year was 65,3. The initial shockable rhythm (pulseless ventricular tachycardia pVT /ventricular fibrillation VF) was registered in 123 /419 (29%), while nonshockable rhythm (asistoly/pulseless electrical activity PEA) in 296/419 (71%) patients. ROSC was achieved in 144/419 (34%) cases. The hospital survival was present in 17/419 (4%) and after 30 days was 16/419 (4%). Oxygen was applied in 179/419 (43%) cases, at 240 (57%)was not used. On scene the oxygen havs been used in 138/179 (77%) cases, during transport in 40/179 (23%). Bag-valve-mask was used in 35/276 (13%) patients, LMA in 14/276 (5%), I-gel in 32/276 (12%) and ETI in 194/276 (70%). Based on the used oxygen therapy and airway management's collected data's, the results indicate that the use of oxygen and the spot where it is used significantly influence the ROSC, where the risk of error is lower than 1% (p |