Endothelial Dysfunction and Cardiovascular Disease: Critical Target for Cell-Based Therapies
| Autor: | Namita Varudkar, Heidi Emrani, Steven N. Ebert, Atul Madan |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Environmental Engineering Endothelium business.industry Disease medicine.disease Industrial and Manufacturing Engineering medicine.anatomical_structure Heart failure Internal medicine medicine Cardiology Myocardial infarction Endothelial dysfunction Progenitor cell Stem cell business Stroke |
| Zdroj: | British Journal of Medicine and Medical Research. 4:3042-3058 |
| ISSN: | 2231-0614 |
| DOI: | 10.9734/bjmmr/2014/7329 |
| Popis: | This review briefly summarizes how cell -based therapeutic interventions are being developed and applied to treat endothelial dysfunction (ED) as a critical clinical target. ED directly contributes to the onset and prognosis for all of the major forms of cardiovascular diseases, including atherosclerosis, pulmonary artery hypertension, peripheral hypertension, stroke, myocardial infarction and congestive heart failure. Current pharmacological therapies used to t reat ED are discussed and compared with newer strategies employing endothelial progenitor cells (EPCs) and other stem cells for tissue repair/regeneration therapies. Cell -based therapies to treat ED are still largely experimental but they are emerging in tand represent a promising avenue for new interventional options to combat cardiovascular disease and improve patient outcomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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