Skeletal Muscle Function, Oxygenation and Biochemistry in an Endotoxemic Model of Sirs
| Autor: | T. E. J. Gayeski, Ellen D. Iannoli |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
business.industry Septic shock Organ dysfunction medicine.disease Systemic inflammatory response syndrome Sepsis medicine.anatomical_structure Bacteremia Internal medicine medicine Cardiology Vascular resistance Leukocytosis medicine.symptom business Multiple organ dysfunction syndrome |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781461374657 |
| DOI: | 10.1007/978-1-4615-5399-1_47 |
| Popis: | Traditionally, “sepsis” refers to bacteremia leading to arteriolar vasodilatation and signs of generalized infection. Sepsis may progress to septic shock, often characterized by hypotension, classically explained as pooling of blood in the peripheral microcirculation.1 A similar clinical picture in patients with no laboratory evidence of infection has been called the “septic syndrome.”9 Many of the characteristics of sepsis and the septic syndrome are mediated by host inflammatory products. The more comprehensive title systemic inflammatory response syndrome (SIRS) encompasses both states as well as states with similar clinical characteristics such as burn injuries.16 The clinical signs of SIRS are fever, tachycardia, low systemic vascular resistance, tachypnea, and leukocytosis or leuk- openia. Organ dysfunction may ensue despite adequate cardiac output and arterial oxygen tension. When more than 2 organs are dysfunctional, the patient is said to have multiple organ dysfunction syndrome (MODS). In patients the development of MODS leads to high mortality and great expense. Understanding the pathophysiology of SIRS may lead to improved therapy, lower mortality and reduced cost.16 |
| Databáze: | OpenAIRE |
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