| Autor: |
Jose Ruiz, Vishakha Bhave, Noah Tedla, Xinyu Wang, Vicky Mody |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nanocarriers: Drug Delivery System ISBN: 9789813344969 |
| Popis: |
The use of nanoparticles in medicine has improved the options for diagnosis and therapy. Numerous diseases that were previously thought to be challenging are now addressed with the advent of nanoparticles. This is possible due to the ability of nanoparticles to selectively target desired tissue/cells and communicate with the cellular environment at nanoscale levels. Although nanomedicine has innumerous advantages over traditional medicine, the use of nanoparticles comes with its own baggage of special pharmacokinetic parameters and toxicity. Hence it becomes imperative to understand the development of nanoparticles from bench to clinic with emphasis on its pharmacokinetic properties and toxicity. With this objective in mind we have discussed the synthesis of clinically important metallic and nonmetallic nano-drug carriers and the process to alter their physicochemical properties for their application in therapy and/or diagnosis. This is followed by a discussion of the pharmacokinetic properties of selected nano-drug carriers that make them desirable for formulations as an efficient drug delivery system. Lastly, the chapter discusses potential toxicities that are associated with nanocarriers, mechanisms of toxicity, major target organs, and factors influencing these toxicities. We have concluded this chapter by discussion of two clinically used nano-drug carriers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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