The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model
| Autor: | Buwei Yu, Weifeng Yu, Lijiao Chen, Rong Dong |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Agonist Cancer Research medicine.medical_specialty Ketanserin medicine.drug_class Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine medicine Receptor Dimethyl sulfoxide Antagonist General Medicine Spinal cord Molecular medicine 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Apoptosis Anesthesia 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Experimental and Therapeutic Medicine. 12:3583-3588 |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Postoperative pain is a critical problem in clinical pain administration. Due to the unclear formation mechanism of postoperative pain, the treatment of postoperative pain is still in the symptomatic treatment stage and lacking satisfactory analgesic effect. Postoperative pain can be simulated by using a rat incision pain model. We observed changes in pain-related behavior of rats affected by the 5-hydroxytryptamine 2A receptor (5-HT2AR) agonist, TCB-2, and antagonist, ketanserin, through intrathecal delivery. The transcription and translation level of potassium-chloride cotransporter 2 (KCC2) in the spinal cord was also measured to investigate the role of the 5-HT2AR-KCC2 pathway in the mechanism of incision pain. Compared with the control group, rats in the incision pain group had decreased mechanical withdrawal threshold (MWT), with significant differences on day 1-7 after surgery, and significant decreases in thermal withdrawal latency (TWL) on days 1, 2, 3 and 6 (P |
| Databáze: | OpenAIRE |
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