HEPATOPROTECTIVE EFFECT OF AQUEOUS LEAF EXTRACT OF Psidium guajava IN KETOCONAZOLE-TREATED ADULT MALE WISTAR RATS
| Autor: | S. O. INNIH, P. I. OSIRIKE, A. UBHENIN, M. EHI-OMOSUN, E. O. IMAFIDON |
|---|---|
| Rok vydání: | 2022 |
| Zdroj: | Nigerian Journal of Life Sciences (ISSN: 2276-7029). 6:218-224 |
| ISSN: | 2814-2586 2276-7029 |
| DOI: | 10.52417/njls.v6i1.302 |
| Popis: | Ketoconazole is an imidazole-derived drug used in the treatment of a broad-spectrum offungal diseases. It is also believed to be hepatotoxic. This present study investigatesthe effect of aqueous leaf extract of Psidium guajava on liver function parameters inadult male wistar rats treated with ketoconazole. Twenty rats were divided into fourgroups, with five rats per group. Group 1 animals were the control animals; group 2animals received 20mg/kg body weight of ketoconazole for 60 days. Animals in groups3 and 4 were pre-treated with 400mg/kg and 200mg/kg body weight of aqueous leafextract of Psidium guajava respectively for 30 days and then induced with 20mg/kgbody weight of ketoconazole for 30 days. Serum levels of alanine aminotransferase,aspartate aminotransferase, alkaline phosphatase, total protein, total and conjugatedbilirubin, albumin and globulin were estimated. From the results obtained, administrationof only ketoconazole did not have any significant effect (p>0.05) on all the liver functionparameters studied, except for alanine aminotransferase level which was significantlyelevated (p0.05) on all the other parameters studied. Thisindicates that Psidium guajava, especially at low doses, has hepatoprotective activity inketoconazole-treated rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|