2-Acetoxybriaranes from Briareum violaceum

Autor:	Jia-Wen Yao, Tzu-Rong Su, Yu-Jen Wu, Ping-Jyun Sung, Gene-Hsiang Lee, Jyh-Horng Sheu, Jui-Hsin Su, Tsong-Long Hwang, Wei-Chiung Chi
Rok vydání:	2019
Předmět:	Briareum violaceum biology 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Drug Discovery Elastase 010402 general chemistry biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences
Zdroj:	Tetrahedron. 75:3751-3757
ISSN:	0040-4020
DOI:	10.1016/j.tet.2019.05.053
Popis:	Five 2-acetoxybriaranes, including two known analogues, excavatolides B (1), E (2), along with three new metabolites, briaviolides V–X (3–5), have been obtained from the octocoral Briareum violaceum. The absolute configurations of 1 and 2 were determined by X-ray analysis for the first time and the structures of 3–5 were established by spectroscopic methods. Bioactivity study showed that briarane 3 decreased the release of elastase from human neutrophils.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eaee769e77737d78964e8207d0566bcc https://doi.org/10.1016/j.tet.2019.05.053 Zobrazit plný text záznamu Full Text from ScienceDirect