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Objective: The purpose of this study is to identify determinants of erectile dysfunction in hemodialysis patients in CNHU-HKM, Cotonou. Method: It was a cross-sectional, descriptive and analytical study conducted over a period of six months, from 1st March to 30th August 2017. Prospective data collection was carried out, along with a comprehensive census of hemodialysis patients meeting inclusion criteria. Sexual function was assessed through full version of International Index of Erectile Function (IIEF). Results: 114 hemodialysis patients were included in the study, with mean age estimated at 51.05 years ± 11.66. Among the study population, 100 patients (87.7%) had hypertension as comorbidity, hypertensive Nephropathy (67.5%) and Diabetic Nephropathy (14%). The average duration on dialysis was 74.34 ± 55.74. Forty-three hemodialysis patients (37.7%) were with depression, 56 (49.1%) had lower testosterone, 38 (33.3%) high rate of LH and 63 (55.3%) high FSH. 98 (86%) of them experienced erectile dysfunction, 97 (85.1%) sexual desire disorder and 80 (70.2%) orgasm disorder. Determinants of erectile dysfunction in hemodialysis patients included age (p |