Low membrane protein sulfhydrils but not glucose-6-phosphate dehydrogenase deficiency predict ribavirin-induced hemolysis

Autor:	I. Grattagliano, Stefan Russmann, V. O. Palmieri, Bernhard H. Lauterburg, G. Palasciano, F. Bihl, P. Portincasa
Rok vydání:	2004
Předmět:	Pharmacology Chemistry Thiobarbituric acid Ribavirin Erythrocyte fragility Glutathione medicine.disease medicine.disease_cause Hemolysis Dipyridamole chemistry.chemical_compound Biochemistry medicine Pharmacology (medical) Oxidative stress Glucose-6-phosphate dehydrogenase deficiency medicine.drug
Zdroj:	Clinical Pharmacology & Therapeutics. 75:P57
ISSN:	0009-9236
Popis:	Purpose Hemolysis is a frequent adverse effect of ribavirin (RBV). Oxidative stress has been suggested to play a role, but mechanisms and predictive risk factors are unknown. Methods: Markers of redox status were determined in erythrocytes from hepatitis C infected patients with and without G6PD-deficiency before and during RBV treatment, and erythrocytes were incubated with RBV and dipyridamole, diethylmaleate or glutathione ester. Results: 5 out of 30 patients developed major RBV-induced hemolysis, which was associated with a more pronounced increase in thiobarbituric acid reactive substances (+22.5 vs. +9.4 nmol/gHb, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::eae3a09d2aa10b5339576f8328b07439 https://doi.org/10.1016/j.clpt.2003.11.216 Zobrazit plný text záznamu Plný text