Evaluación farmacocinética/farmacodinámica (PK/PD) de un esquema de administración oral de metronidazol en intervalo ampliado para el manejo de infecciones producidas por Bacteroides fragilis
| Autor: | Sergio Mella-Montecinos, Cindy Sanhueza-Sanhueza, Helia Bello-Toledo, Lorenzo Villa-Zapata, Felipe Morales-León, Pola Fernández-Rocca, Carlos von Plessing-Rossel |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.drug_class Antibiotics Public Health Environmental and Occupational Health Cmax Pharmacology biology.organism_classification Surgery Metronidazole Infectious Diseases Pharmacokinetics Oral administration Medicine Bacteroides fragilis business Anaerobic exercise PK/PD models medicine.drug |
| Zdroj: | Revista chilena de infectología. 32:135-141 |
| ISSN: | 0716-1018 |
| DOI: | 10.4067/s0716-10182015000300001 |
| Popis: | Introduction Metronidazole is the antibiotic of choice for the management of infections caused by anaerobes. Its administration requires multiple daily doses causing increased medication errors. Due to its high post-antibiotic effect and rapid concentration-dependent bactericidal activity, administration of this antibiotic in an extended dosing interval would achieve PK/PD parameters effectively. Objective To assess the probability of achieving effective PK/PD relationship with the administration of 1,000 mg every 24 hours of metronidazole for Bacteroides fragilis infections. Methods A clinical trial was conducted in a group of volunteers who received a single oral dose of 500 or 1,000 mg of metronidazole. Determinations of values of Cmax, t max, and AUCC0-24 h. determined using the trapezoidal method, were obtained for a Markov simulation that would allow for determining the likelihood of achieving a AUC0-24 h/MIC ratio above 70 for infections caused by susceptible B. fragilis. Results Cmax (24,03 ± 6,89 mg/L) and t max (1,20 ± 0.80 hrs) and the value of AUC0-24 h (241.91 ± 48.14 mg * h/L) were determined. The probability of obtaining a AUC0-24 h/MIC ratio greater than 70 was greater than 99%. Conclusion From a pharmacokinetic perspective, with the administration of a daily dose of 1,000 mg of metronidazole, it is possible to achieve a therapeutic goal of AUC0-24 h/MIC ratio above 70 for the treatment of anaerobic infections. |
| Databáze: | OpenAIRE |
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