| Popis: |
For studing which α adrenoceptor α1- or α2- receptor) is mainly responsible for ACTH secretion in rats, prazosin and yohimbine were used as selective ρ1- and ς2- adrenoceptor antagonists, respectively, and B-HT933 was used as a selective α2- adrenoceptor agonist. Drugs were injected i.p., except for prazosin which was injected s.c. Rats were decapitated after suitable periods and the trunk blood was collected. The amount of ACTH in the serum was determined by a bioassay. (1) ACTH secretion induced by phenylephrine was inhibited by prazosin (P |
