Understanding Behavior of Polycaprolactone–Gelatin Blends under High Pressure CO2
| Autor: | David L. Tomasko, John J. Lannutti, Hrishikesh Ramesh Munj |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
food.ingredient Materials science Polymers and Plastics 0206 medical engineering 02 engineering and technology Polymer 021001 nanoscience & nanotechnology 020601 biomedical engineering Gelatin Supercritical fluid chemistry.chemical_compound food chemistry Chemical engineering Polycaprolactone Materials Chemistry Stress relaxation medicine Swelling medicine.symptom 0210 nano-technology Porosity Dissolution |
| Zdroj: | Polymer Science, Series A. 59:866-879 |
| ISSN: | 1555-6107 0965-545X |
| Popis: | Polycaprolactone (PCL) is widely used in biomedical applications as electrospun fibers or porous foams. As PCL is synthetic polymer, many researchers have explored blends of PCL–gelatin to combine mechanical and bioactive properties of individual components. High pressure carbon dioxide (CO2) has been studied to foam and impregnate many biocompatible polymers. In case of PCL–gelatin blends, certain compositions can be swelled reversibly under high pressure CO2 without permanent deformation. This allows successful impregnation of PCL–gelatin blends under CO2. This study summarizes effect of different treatments adopted during impregnation process including high pressure CO2 on several blend compositions of PCL–gelatin blends. Stress relaxation, polymer melting and dissolution were observed during several treatments which affects porosity and scaffold structure significantly. Results summarized in this study will aid in optimum selection of PCL–gelatin blend composition for biomedical applications. Furthermore, CO2 solubility in polymers is restricted due to thermodynamic limitations but can be altered in the presence of a co-solvent to produce better foams. PCL can be foamed using supercritical CO2. However, CO2 foaming of PCL–gelatin blend becomes challenging to simultaneous swelling of PCL and compression of gelatin providing blend structural stability. This study has demonstrated ability of supercritical CO2 to foam PCL–gelatin blends in presence of water to create porous structure. These foams were subjected post-fabrication crosslinking and supercritical CO2 without losing porosity of foams. Thus, creating a strategy to use environmentally benign processes to fabricate, crosslink and impregnate porous scaffolds for biomedical applications. |
| Databáze: | OpenAIRE |
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