LC–MS/MS and NMR Characterization of Key Impurities in Linagliptin and Pramipexole

Autor:	Y. Ravindra Kumar, Swetha Parsha, M. Ravichander
Rok vydání:	2015
Předmět:	Pramipexole Chemistry Insulin medicine.medical_treatment Clinical Biochemistry Pharmaceutical Science Incretin Pharmacology medicine.disease Linagliptin Biochemistry Dopamine agonist Glucagon Analytical Chemistry Diabetes mellitus medicine medicine.drug Hormone
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 38:1699-1712
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826076.2015.1087861
Popis:	A sensitive, rugged, and robust LC-MS/MS and NMR analysis has been developed for the identification and characterization of key impurities of Linagliptin and Pramipexole. Linagliptin is used in the treatment of Type-2 diabetes. Linagliptin is a DPP-4 inhibitor which is an enzyme that degrades the incretin hormones (glucagon like peptide-1(GLP)) and glucose dependent insulinotropic polypeptide (GIP). Both these hormones increase insulin biosynthesis and secretion from pancreatic beta cells in the presence of normal and elevated blood glucose 20 levels. Pramipexole is a dopamine agonist of the non-ergoline class indicated for the treatment of Parkinson’s disease and restless legs Q1 syndrome. Parkinson’s disease is a neurodegenerative disease that affects the basal ganglia component, i.e., substantial nigra. Observed one of the key impurities in the analytical HPLC at around 1.30RRT in Lingliptin. To further characterize the impurity, the impurity was synthesized in presence of dibromo methane and was subje...
Databáze:	OpenAIRE
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