The Comparative Immunosuppressive Effects of Heterologous Antisera to Various C3H Mouse Tissues
| Autor: | A. E. Sloboda, Jane Landes |
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| Rok vydání: | 1970 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 104:185-194 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.104.1.185 |
| Popis: | Three different batches of rabbit anti-mouse thymocyte serum (RAMTS) were consistently more effective than simultaneously prepared antisera to mesenteric lymph nodes (RAMLS) in prolonging survival of ICR skin allografts on C3H mice. Antispleen sera (RAMSpS) were ineffective. It was concluded that cells from different lymphoid organs were not equally effective in evoking antisera capable of prolonging skin allograft survival. Dose response experiments indicated that differences in the ability of RAMTS or RAMRS to prolong allograft survival were qualitative rather than quantitative. Neither the time of antiserum collection nor apsorption with mouse erythrocytes affected the ability of RAMTS or RAMLS to prolong allograft survival. Rabbit antisera to the following mouse tissues were ineffective in prolonging mouse skin allograft survival: liver (RAMLiS), kidney (RAMKiS), transplantable C3H mammary tumor (RAM72jS) and transplantable 6C3HED lymphosarcoma of thymic origin (RAM6C3HEDS). All antisera showed high leukoagglutination titers against lymphocytes and thymocytes. Leukoagglutination did not, however, correlate with allograft survival. Lymphopenia induced by either RAMTS or RAMLS treatment did not correlate with effects on allograft survival. Administration of antisera produced an initial increase in nonlymphocytic leukocytes (monocytes and granulocytes) which seemed related to the length of allograft survival. |
| Databáze: | OpenAIRE |
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