Plasma membrane signal-transducing ATP

Autor: Karelin Aa, Demidova Vs, Globa Ag
Rok vydání: 1999
Předmět:
Zdroj: Bulletin of Experimental Biology and Medicine. 128:661-667
ISSN: 1573-8221
0007-4888
Popis: Plasma membranes of target cells generate considerable amounts of ATP in response to binding of growth factors, cytokines, and oncoproteins. Plasma membrane ATP is formed at the stage of ligand-receptor signal transduction by the anaerobic pathway with the involvement of plasma membrane redox systems and Na+ (but not adenylate cyclase). The assumption on the involvement of transitory reversed Na+, K+-ATPase in the synthesis of plasma membrane ATP is confirmed by inhibitory analysis. ATP-producing activity of plasma membrane-enriched particles isolated from various target cells in response to various growth factors was studied. The formation of plasma membrane ATP is stimulated by growth factors and cytokines interacting with integral tyrosine kinase receptors or soluble tyrosine kinases in the cytosol. Various tyrosine kinase inhibitors act by utilizing plasma membrane ATP. Plasma membrane ATP is assumed to be a messeger and amplifier of ligand-receptor signals in plasma membranes of animal cells.
Databáze: OpenAIRE
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