Organophotoredox-Catalyzed Oxidative C(sp2)–H Alkylation of N-Heteroarenes with Dihydroquinazolinones by C–C Cleavage

Autor:	Basudev Sahoo, Shubham Ojha, Anagha Veluthanath Nair, Sariga Mangalamundackal Vijayan, Pinku Prasad Mondal, Amit Pal, Subham Das
Rok vydání:	2023
Předmět:	Organic Chemistry
Zdroj:	Synlett.
ISSN:	1437-2096 0936-5214
DOI:	10.1055/a-2030-7826
Popis:	We report a visible-light-mediated, organophotoredox-catalyzed, C(sp2)–H alkylation of N-heteroarenes with dihydroquinazolines, prepared from aliphatic ketones, under oxidative conditions. This protocol represents a metal-free approach to the effective construction of C–C bonds through a Minisci-type reaction, formally activating the native C–H bond of the N-heteroarene and an α-C–C bond of a readily available ketone. The mild nature of this method accommodates a wide variety of N-heteroarenes and ketones, tolerating a wide range of functional groups.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ead3ea3af0c6194e47b915a29d62c985 https://doi.org/10.1055/a-2030-7826 Zobrazit plný text záznamu