Age-Related Features of α-Synuclein Pathology in the Brain on Modeling the Preclinical Stage of Parkinson’s Disease in Rats
| Autor: | D. V. Plaksina, I. V. Ekimova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Parkinson's disease Lactacystin Substantia nigra Biology law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Confocal microscopy law mental disorders medicine Pathological General Neuroscience Dopaminergic medicine.disease nervous system diseases Olfactory bulb 030104 developmental biology nervous system chemistry Cytoplasm 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and Behavioral Physiology. 50:109-114 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-019-00875-0 |
| Popis: | The pathomorphological signs of Parkinson’s disease (PD), an untreatable neurodegenerative condition, include the formation of pathological α-synuclein-positive inclusions in neurons. Studies using a model of the preclinical stage of PD in middle-aged and elderly rats based on increasing suppression of brain proteasome activity, along with analysis by light and confocal microscopy, addressed the presence and locations of pathological α-synuclein-positive inclusions in dopaminergic neurons in the compact part of the substantia nigra (SNc) and olfactory bulb. In the model of BP, α-synuclein aggregates were located in the cytoplasm of dopaminergic neurons in the olfactory bulb and the cytoplasm and nuclei of dopaminergic neurons in the SNc. A characteristic feature of α-synuclein pathology in aging rats was deposition of larger α-synuclein aggregates in the bodies of nerve cells in these locations as compared with middle-aged rats. |
| Databáze: | OpenAIRE |
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