ChemInform Abstract: Cyclic Thioether Peptide Mimetics as VCAM-VLA-4 Antagonists

Autor:	Barry A. Wolitzky, Virginia Schwinge, Karen Rowan, Pramod Joshi, Jefferson Wright Tilley, Nader Fotouhi
Rok vydání:	2000
Předmět:	inorganic chemicals chemistry.chemical_classification Stereochemistry Disulfide bond chemistry.chemical_element VLA-4 Peptide General Medicine Sulfur Ring size chemistry.chemical_compound Thioether chemistry Bromide Intramolecular force
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
Popis:	Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependant on ring size and the position of the sulfur atom.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ead0d1bfcea91bb1de946b709b590a60 https://doi.org/10.1002/chin.200039150 Zobrazit plný text záznamu Plný text