Remote-Controlled Hydrogel Depots for Time-Scheduled Vaccination
| Autor: | Hanna Seitz, Martin Werner, Ghislaine Charpin-El Hamri, Balder Rebmann, Wilfried Weber, Ronald Schoenmakers, Raphael J. Gübeli, Martin Ehrbar, Marie Daoud-El Baba, Désirée Hövermann, Martin Müller |
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| Rok vydání: | 2013 |
| Předmět: |
Drug
0303 health sciences Materials science Stimuli responsive media_common.quotation_subject Nanotechnology 02 engineering and technology Stimulus (physiology) Pharmacology 021001 nanoscience & nanotechnology Condensed Matter Physics 3. Good health Electronic Optical and Magnetic Materials Biomaterials Vaccination 03 medical and health sciences Human use Electrochemistry Human papillomavirus 0210 nano-technology 030304 developmental biology media_common |
| Zdroj: | Advanced Functional Materials. 23:5355-5362 |
| ISSN: | 1616-301X |
| DOI: | 10.1002/adfm.201300875 |
| Popis: | Remote-controlled drug depots represent a highly valuable tool for the timely controlled administration of pharmaceuticals in a patient compliant manner. Here, the first pharmacologically controlled material that allows for the scheduled induction of a medical response in mice is described. To this aim, a novel, humanized biohybrid material that releases its cargo in response to a small-molecule stimulus licensed for human use is developed. The functionality of the material in mice is demonstrated by the remote-controlled delivery of a vaccine against the oncogenic human papillomavirus type 16. It is shown that the biohybrid depot-mediated immunoprotection is equivalent to the classical multi-injection-based vaccination. These results indicate that this material can be used as a universal remote-controlled vehicle for the patient-compliant delivery of vaccines and pharmaceuticals. |
| Databáze: | OpenAIRE |
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