Silver Triflate Catalyzed Synthesis of Isoquinolino[2,1-a]quinazolino[3,2-c]quinazoline Derivatives via Alkyne Hydroamination
| Autor: | Wan-Chen Pan, Jian-Quan Liu, Mei-Mei Zhang, Xiang-Shan Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry Alkyne 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Benzaldehyde chemistry.chemical_compound chemistry Intramolecular force Quinazoline Hydroamination Isoquinoline Trifluoromethanesulfonate |
| Zdroj: | Synthesis. 51:3101-3108 |
| ISSN: | 1437-210X 0039-7881 |
| Popis: | Using 2-(2-aminophenyl)quinazolin-4(3H)-one and 2-(2-phenylethynyl)benzaldehyde as the reactants, silver triflate (AgOTf) was proved to be an efficient catalyst to promote not only quinazoline cyclization, but also the intramolecular hydroamination of alkyne for the synthesis of 6-aryl-17H,18aH-isoquinolino[2,1-a]quinazolino[3,2-c]quinazolin-17-one derivatives in high yields. |
| Databáze: | OpenAIRE |
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