Markers of systemic inflammation in children with hyperuricemia
| Autor: | Edyta Tenderenda, Anna Wasilewska, Justyna Stypułkowska, Jolanta Tobolczyk, Katarzyna Taranta-Janusz |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry Monocyte Inflammation Mean age General Medicine Serum concentration Systemic inflammation medicine.disease Obesity chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Pediatrics Perinatology and Child Health medicine Uric acid Hyperuricemia medicine.symptom business |
| Zdroj: | Acta Paediatrica. 101:497-500 |
| ISSN: | 0803-5253 |
| DOI: | 10.1111/j.1651-2227.2011.02582.x |
| Popis: | Aim: The purpose of the study was to investigate serum concentrations of the monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity CRP (hs-CRP) in children with hyperuricemia and to evaluate its association with obesity. Patients and Methods: The study involved 52 hyperuricemic patients with mean age of 15.53 ± 1.7 years. Twenty-seven healthy individuals with normal serum uric acid (SUA) level were selected as the control group (C). Serum MCP-1 and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA) and immunonephelometry, respectively. Results: Hyperuricemic patients showed increased sMCP-1 (median: 69.58 pg/mL) and hs-CRP (median: 0.53 mg/L) vs. controls (48.39 pg/mL, 0.24 mg/L; respectively) (p 0.05). Conclusion: Serum MCP-1 and hs-CRP are elevated in hyperuricemic patients, but the role of obesity in inflammation markers needs further investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text