Impact of adventitial neovascularisation on atherosclerotic plaque composition and vascular remodelling in a porcine model of coronary atherosclerosis
| Autor: | David Wallace-Bradley, Chao Yuh Yang, Armando Tellez, Christie M. Ballantyne, Greg L. Kaluza, Angela Sanguino, Carlos L. Alviar, Daryl G. Schulz, Gabriel Lopez-Berestein, Juan F. Granada, Angela Builes |
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| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Vascular disease Anatomy musculoskeletal system medicine.disease medicine.disease_cause Vulnerable plaque Vascular remodelling in the embryo Neovascularization Stenosis medicine.anatomical_structure In vivo Medicine medicine.symptom Cardiology and Cardiovascular Medicine business Coronary atherosclerosis Blood vessel |
| Zdroj: | EuroIntervention. 5:981-988 |
| ISSN: | 1774-024X |
| DOI: | 10.4244/eijv5i8a164 |
| Popis: | AIMS There is little in vivo data in regards to the impact of adventitial neovascularisation on vascular remodelling and plaque composition. Using a porcine model of coronary atherosclerosis, we aimed to determine the impact of adventitial neovascularisation on plaque composition and vascular remodelling evaluated by IVUS. METHODS AND RESULTS Coronary atherosclerosis was induced by adventitial delivery of lipids and a high cholesterol diet. At termination all vessels were analysed using IVUS to determine the degree of remodelling of each individual segment containing atherosclerotic lesions. Then, each segment was correlated with its correspondent histological frame for plaque composition and neovessel density. A total of 57 atherosclerotic lesions at different stages of development were analysed. The total neovessel count (TNC) correlated to the degree of plaque burden (15.6+/-7.2 TNC in 60% stenosis, p |
| Databáze: | OpenAIRE |
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